Services

We bring expertise in all aspects of membrane protein production, structural biology, and hit discovery. Our cutting-edge technologies, collaborative approach, and flexible contract options are tailored to meet your specific research and drug discovery needs. We also offer free feasibility assessments to ensure we’re the right partner for your project.

Protein Sciences

We deliver high-quality proteins tailored to your needs, combining cutting-edge technologies with our deep expertise in construct design, expression, and purification. Our streamlined processes ensure precision, scalability, and reliability.

What we offer:

Gene-to-protein services
Off-the-shelf proteins (90+, list upon request)
Construct engineering and optimization
Purity, homogeneity, stability, and functional testing

Curious about our expertise? Contact us to discover the range of proteins we’ve successfully worked with and how we can support your project.

Biophysical Characterization of Membrane Proteins

Uncover the critical data you need to make informed decisions with our advanced biophysical characterization services. Using state-of-the-art tools, we provide actionable insights into molecular interactions and stability.

What we offer:

Characterization and quantification of client compounds for target engagement, affinity, kinetics, competition, allosteric modulation, thermodynamics (GCI, MST/TRIC, MS)
Protein thermal stability / thermal shift assays (DSF, nanoDSF, CPM, FSEC-TS)
Molecular and particle sizing, oligomerization, aggregation (DLS, SLS)
Nanobody/antibody binding characterization (GCI, analytical SEC)

Discover how our cutting-edge technologies, like Grating-Coupled Interferometry (GCI), elevate biophysical assay precision. Learn more about our approach on the Technology Platform.

Structural Biology

Solve the most complex structural challenges with our expertise in structural biology. From initial grid freezing to high-resolution structure determination, we provide comprehensive support for your projects.

What we offer:

X-ray crystallography and CryoEM services
Negative staining EM
Cryo-EM grid freezing optimization
Crystallization screening and structure refinement
Serial and time-resolved crystallography

Discover how our structural biology expertise delivers results. From advancing GPCR drug discovery to solving transporter and ion channel structures, and leveraging free elector lasers for groundbreaking insights—our case studies showcase the impact we can achieve together.

Computational Chemistry

Accelerate discovery with our advanced computational chemistry services. We bridge in silico insights with experimental validation to drive results faster and more efficiently.

What we offer:

Structure-based virtual screening using ultra-large combinatorial libraries
Binding pose modeling using induced fit docking and free energy methods
Structure-based drug design
Ligand-protein interaction analysis
In-silico mutagenesis for protein engineering

See our computational chemistry in action. Explore our vision to learn how we identified high-quality hits from ultra-large libraries, driving faster and more efficient drug discovery.

Lead Discovery

Take your discovery projects from hit identification to lead optimization with our integrated approach. Combining medicinal, synthetic, and computational chemistry with biophysical and structural insights, we guide you every step of the way.

What we offer:

Hit-to-lead optimization
Lead candidate selection
Multi-disciplinary project management

Discover how we advanced the GPR68 project in collaboration with Cumulus Oncology. Explore our case study to see how we supported the hit-to-lead process and optimized candidates for impactful drug discovery.

Next Steps

Together, we accelerate structure-based drug discovery programs for membrane proteins. Explore our case studies to see our success in action, or contact us to discuss how we can support your next breakthrough.

Need more reasons?

Here are some of the reasons why our partners love working with us:

Confidentiality

IP and Target Exclusivity

Expert Membrane Protein Scientists

Expertise in Membrane Proteins

Flexible Contracts

Unique Technologies