Skip to content


    • T. Claff et al. Crystal structure of adenosine A2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction. Commun. Chem., doi: 10.1038/s42004-023-00894-6
  • Showcase of Promacrobody (PMbs) technology:

    • M. Botte et al. Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation. Nat. Commun. 2022, doi: 10.1038/s41467-022-29459-2

    • Y. Lan et al. Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses. J. Immunother. Cancer 2022, doi: 10.1136/jitc-2021-004122

    First structure at the time of a human Kv3:

    • M. Botte et al. Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 reveal a novel binding site for positive modulators. PNAS Nexus 2022, doi: 10.1093/pnasnexus/pgac083
    • D. Bucher et al. Discovery of selective inhibitors of A2B adenosine receptors. Poster presented at the RSC/SCI Symposium on GPCRs in Verona, 2022, link