Publications
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- T. Claff et al. Crystal structure of adenosine A2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction. Commun. Chem., doi: 10.1038/s42004-023-00894-6
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Showcase of Promacrobody (PMbs) technology:
- M. Botte et al. Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation. Nat. Commun. 2022, doi: 10.1038/s41467-022-29459-2
- Y. Lan et al. Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses. J. Immunother. Cancer 2022, doi: 10.1136/jitc-2021-004122
First structure at the time of a human Kv3:
- M. Botte et al. Apo and ligand-bound high resolution Cryo-EM structures of the human Kv3.1 reveal a novel binding site for positive modulators. PNAS Nexus 2022, doi: 10.1093/pnasnexus/pgac083
- D. Bucher et al. Discovery of selective inhibitors of A2B adenosine receptors. Poster presented at the RSC/SCI Symposium on GPCRs in Verona, 2022, link
- M. Botte et al. Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation. Nat. Commun. 2022, doi: 10.1038/s41467-022-29459-2
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- C. Rufer and M. Hennig, Biophysical Assessment of Target Protein Quality in Structure-Based Drug Discovery, in Structural Biology in Drug Discovery 2020, doi: 10.1002/9781118681121.ch7
- R. K. Cheng, Towards an Optimal Sample Delivery Method for Serial Crystallography at XFEL, Crystals 2020, doi: 10.3390/cryst10030215
- K. Nass et al. Advances in long-wavelength native phasing at X-ray free-electron lasers IUCrJ, 2020, doi: 10.1107/S2052252520011379
- R. Cheng et al. In situ crystallography as an emerging method for structure solution of membrane proteins: the case of CCR2A, FEBS J 2020, doi: 10.1111/febs.15098
- M. Botte et al. Cryo-EM structural studies of the agonist complexed human TRPV4 ion-channel reveals novel structural rearrangements resulting in an open-conformation, bioRxiv 2020, doi: 10.1101/2020.10.13.334797
- C. Rufer and M. Hennig, Biophysical Assessment of Target Protein Quality in Structure-Based Drug Discovery, in Structural Biology in Drug Discovery 2020, doi: 10.1002/9781118681121.ch7
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- A.-K. Apel et al. Crystal Structure of CC Chemokine Receptor 2A in Complex with an Orthosteric Antagonist Provides Insights for the Design of Selective Antagonists, Structure 2019, doi: 10.1016/j.str.2018.10.027
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- T. Weinert et al. Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons, Nat. Commun. 2017, doi: 10.1038/s41467-017-00630-4
- K. Y. Cheng, R. Abela, and M. Hennig, X-ray free electron laser: opportunities for drug discovery,
Essays Biochem 2017, doi: 10.1042/EBC20170031 - P. Rucktooa et al. Towards high throughput GPCR crystallography: In Meso soaking of Adenosine A2A Receptor crystals, Sci. Rep 2018, doi: 10.1038/s41598-017-18570-w
- T. Weinert et al. Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons, Nat. Commun. 2017, doi: 10.1038/s41467-017-00630-4
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- J.-P. Renaud et al. Biophysics in drug discovery: impact, challenges and opportunities Nat. Rev. Drug Discov 2016, doi: 10.1038/nrd.2016.123