Remove the Pain, Retain the Gain!
Biophysical Methods in Early Drug Discovery
Join us for an inspiring webinar with our Senior Scientist, Fabio Andres!
Tuesday 13th June 2023
16.00 CEST / 10.00 EDT / 07.00 PDT 09.00 CEST / 16.00 Beĳing, Singapore / 17.00 Tokyo, Seoul
Webinar Replay Session:
Wednesday 21st June 2023
16.00 CEST / 10.00 EDT / 07.00 PDT
09.00 CEST / 16.00 Beĳing, Singapore / 17.00 Tokyo, Seoul
Webinar Summary (by Axxam S.p.A)
Early drug discovery requires an interdisciplinary approach with a sophisticated interplay between empirical methods and rational design.
Amongst the different therapeutic modalities, orally available small molecules are a major pillar for safe treatment of acute and chronic diseases. Especially for novel targets, screening large libraries of drug-like molecules is the method of choice to GAIN valuable information for medicinal chemistry. However, even today’s innovative assays are suffering from false positives due to non-specific interactions of compounds which are described as “PAINs”. Therefore, a crucial step is the validation of hits to show specific binding to the target of interest.
We introduce biophysical methods with microtiter plate-based readouts in solution and chip-based detection by immobilizing the target of interest. We show how these methods are applied in direct binding assays for different target classes.
Furthermore, such assays can also be applied for primary screening of targets which were until recently considered PAINfully undruggable. For example, to identify small molecules binding to miRNAs as needed in the design of RIBOTACs for targeted RNA degradation.
Biophysical methods can not only retain the GAIN for traditional targets but can also provide GAIN in hit identification for emerging drug targets.