leadXpro and Lundbeck partner for membrane protein structure research

Villigen, Switzerland, 7th of October 2019 – leadXpro announces the execution of an agreement with Lundbeck to enable structure-based drug discovery of membrane protein targets. The agreement concerns the research on multiple small molecule drug discovery projects aiming to integrate high resolution membrane protein X-ray and cryo-EM structures for hit finding, characterization and optimization.

Wassim Abdul Rahman, project leader at leadXpro said: “Thanks to our unique in-house developed technologies we are able to generate membrane proteins with great potential to deliver high resolution structural data either by X-ray crystallography or cryo-Electron Microscopy (EM). We are excited to join efforts with Lundbeck to tackle challenging drug targets with great therapeutic interest”

David Rodríguez Díaz, scientific responsible from Lundbeck said: “Our organization strives to continue delivering drugs targeting membrane proteins as excellent therapeutics for brain diseases. To this end, we are very excited about working with leadXpro to enhance our drug discovery efforts by enabling the use of structure-based methods in projects concerning this all-important target class. The scientific and technological prowess of leadXpro, including readily access to X-ray Free Electron Laser sources and cryo-EM experiments, offers a perfect match to our needs in this area.”

About leadXpro AG®

leadXpro is a drug discovery company focusing on membrane protein targets such as GPCR’s, ion-channels and transporters. We are committed to the application of biophysical and structure-based methods for the discovery and optimization of next generation lead compounds with unmet efficacy and specificity. leadXpro’s technology platform capitalizes on the expert knowledge regarding membrane protein biochemistry and close collaboration with academic facilities of the Paul Scherrer Institute (PSI) for synchrotron (SLS), X-ray Free Electron Laser (SwissFEL) and the University of Basel (C-CINA) for single particle cryo-electron microscopy (cryo-EM). For more information, please visit www.leadxpro.com