First structure of human Kv3.1 channel
In collaboration with Lundbeck, leadXpro solved the first structure of a human Kv3 channel in complex with a positive modulator.
case studies
Biostructure success stories from membrane protein projects
CryoEM Structure of Lipopolysaccharide Transporter LptDE Opens the Door to Antibiotics Design
Together with the Basel Biozentrum and the Institute of Medical Microbiology in Zurich, leadXpro solved the structure of the bacterial transporter LptDE to provide structural basis for the design of novel antibiotics.
First Cryo-EM structure of the human TRPV4 ion-channel in the open conformation, in complex with an agonist.
In partnership with Bayer, leadXpro has generated protein and solved the cryo-EM structure of human TRPV4 in complex with the agonist 4α-PDD, providing novel information about agonist binding to this important drug target.
Enabling design of selective antagonists for the CC Chemokine receptor 2A (CCR2A)
In a partnership with Boehringer Ingelheim, leadXpro generated protein and provided the X-ray structure data to advance their drug discovery programs on CCR2, a chemokine receptor target.